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Second Announcement and Call for Abstracts

Fifth International Alkaline Phosphatase Symposium
“Understanding alkaline phosphatase function – Pathophysiology and treatment of Hypophosphatasia and other AP-related diseases”

Huningue, France May 16-19, 2007

Purpose of the conference - Given the large amount of new information gained in the last few years concerning the structure and function of mammalian alkaline phosphatases (APs), the time appears ripe to arrange for a new gathering of researchers in this research area to share new information and to discuss promising new approaches for the treatment of AP-deficiencies, particularly Hypophosphatasia. The first AP symposium, organized by Torgny Stigbrand, took place in Umeå, Sweden, September 16-17, 1983 with a primary emphasis on the immunodetection of AP isozymes and isoforms. The second conference, organized by Marc De Broe, took place in Antwerp, Belgium, September 14-15, 1985 and focused on the role of APs in the pathophysiology of liver, kidney, bone and intestinal diseases. The third conference, organized by José Luis Millán, took place in La Jolla, California, February 1-3, 1989 and had as focus the cloning and characterization of the different mouse and human AP genes and initial studies towards establishing mouse models of AP deficiencies. The fourth conference again organized by Marc De Broe in Antwerp, Belgium, March 13-14, 1992 had a focus on elucidating the significance of membrane-bound versus soluble forms of APs in health and disease. This Fifth Symposium is being organized in Huningue, France under the auspices of “Hypophosphatasie Europe” a public not-for-profit organization that aims to gather and disseminate information on alkaline phosphatases to help patients with Hypophosphatasia and their families. As a consequence the focus of this Symposium is heavily slanted towards understanding the pathophysiology of hypophosphatasia and discussing existing and novel treatments for this disease. However, advances in the understanding of the role of other APs in health problems such as obesity and metabolic syndrome are also becoming apparent and will be discussed at this conference.

Organizing committee

José Luis Millán (La Jolla, California, USA) – President of the Organizing Committee
Steve Ursprung (Huningue, France) – President of Hypophosphatasie Europe
Etienne Mornet (Versailles, France) – President of the scientific committee of Hypophosphatasie Europe

Location
The conference will take place in Huningue, a small town close to Mulhouse and Strasbourg in Alsace (east of France). The Basel International Airport (Switzerland) is 4 kms away from the meeting place. Huningue is the registered office of the foundation “Hypophosphatasie Europe” and there are very beautiful places around, especially typical villages famous for their great architecture and wine. The conference sessions will take place at the cultural center known as Le Triangle. The auditorium has a capacity of 152 persons, with adequate sound and video projection equipment. A hall in front of the room is large enough to accommodate all posters that will be set up and displayed during the entire conference. A large room upstairs will be used for luncheons and coffee breaks. The hotels are not far away and a minibus service will bring participants to and from the hotels at established times.

Travel information :

The symposium may be reached: By road - Autoroute A36 from Lyon / Belfort - Autoroute A35 from Paris / Strasbourg - Autoroute A5 from Karlsruhe / Fribourg (Germany) By train In France SNCF / Train station : Saint-Louis (68300); a minibus will bring participants to the meeting place and to the hotels Online time-tables and booking: http://www.sncf.com In Switzerland SBB in Bâle Online time-tables and booking: http://mct.sbb.ch/mct/en/reisen.htm By airway The international airport Euroairport connects Bâle, Mulhouse and Fribourg. The airport is 4 km away from the meeting place; a minibus service will bring the participants to the hotels and to the meeting place. http://www.euroairport.com

In order to organize the transportation of participants from the train stations or airports, please inform us as soon as you have the information of the time and location of arrival contact@hypophosphatasie.com

 Hotels
The registration includes accommodation fees. Participants will be housed in a four stars hotel five minutes from the meeting place. A minibus service will be available. The registration fees will cover hotel rates (including breakfast).

ATLAS HOTEL **** in Weil am Rhein (D) www.atlas-hotel.de

Accompanying persons

• Due to a limitate availability of rooms, we can accept accompanying persons only if they share the room with a conference attendee.

• The registration fee for accompanying persons are the same as conference attendees.

• A specific social program will be organized for accompanying persons and patients/families of patients who do not whish attempt the scientific sessions.

The procedure is simple:

On the 1st page
1°) Click on the "Pay Now" link
2°) Enter the number of participants that you are paying for
3°) Fill in credit card information and click on "Proceed to checkout"

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Call for abstracts

Participants are strongly encouraged to submit abstracts for presentation at the meeting. The organizers will choose a certain number of abstracts for oral presentation. Additionally strong emphasis will be afforded to poster presentations. All posters will be set up and displayed for viewing throughout the entire conference and two poster sessions are scheduled for Thursday, May 17 and Friday, May 18.

To submit an abstract, please go to the section Abstracts submissions

DEADLINE FOR ABSTRACTS SUBMISSION: February 15, 2007

Preliminary program

Wednesday, May 16
13:00 – 14:15: Registration and placement of posters for the duration of the meeting
14:00Welcome and Opening of the meeting
14:15-18:00 Session I – Clinical presentation and diagnosis of Hypophosphatasia (Keynote speaker: Michael P. Whyte)
18:15 Welcome reception
20:00 Dinner

Thursday, May 17
08:30-10:30 Session II – Molecular pathogenesis of hypophosphatasia
10:30-11:00 Coffee break
11:00-13:00 Session III – Protein Structure
13:00-15:30 Buffet lunch and Poster Session I
15:30 Departure for Riquewihr by bus
17:00 Visit to the village and underground caves
20:00 Dinner at a local wine tavern (Winstub)

Friday, May 18
08:30-10:00 Session IV – Other hypophosphatasia-related abnormalities
10:00-10:30 Coffee break
10:30-12:30 Session V – Therapeutic strategies for hypophosphatasia
12:30-14:30 Lunch and Poster Session II
14:30-17:30 Session VI – Abnormalities caused by deficiencies in other alkaline phosphatase isozymes
17:30 afternoon break
18:30-20:00 Session VIII – Alkaline phosphatases as therapeutic agents for other clinical conditions
20:30 Dinner aboard a ship and sailing on the Rhine towards Basel (to be confirmed)

Saturday, May 19
09:00-12:00 Session IX – Panel discussion and Q&A session for lay audience and hypophosphatasia patients
12:30 Closing of the meeting and farewell lunch